@@ -370,6 +370,7 @@ Interval
 Indexing
 ^^^^^^^^
 - Bug in :meth:`DataFrame.__setitem__` losing dtype when setting a :class:`DataFrame` into duplicated columns (:issue:`53143`)
+- Bug in :meth:`DataFrame.__setitem__` with a boolean mask and :meth:`DataFrame.putmask` with mixed non-numeric dtypes and a value other than ``NaN`` incorrectly raising ``TypeError`` (:issue:`53291`)
 -
 
 Missing

@@ -4074,7 +4074,6 @@ def _setitem_frame(self, key, value):
 "Must pass DataFrame or 2-d ndarray with boolean values only"
 )
 
-self._check_inplace_setting(value)
 self._check_setitem_copy()
 self._where(-key, value, inplace=True)
 

@@ -114,7 +114,6 @@
 is_bool_dtype,
 is_dict_like,
 is_extension_array_dtype,
-is_float,
 is_list_like,
 is_number,
 is_numeric_dtype,
@@ -6201,21 +6200,6 @@ def _is_mixed_type(self) -> bool_t:
 
 return self.dtypes.nunique() > 1
 
-@final
-def _check_inplace_setting(self, value) -> bool_t:
-"""check whether we allow in-place setting with this type of value"""
-if self._is_mixed_type and not self._mgr.is_numeric_mixed_type:
-# allow an actual np.nan through
-if (is_float(value) and np.isnan(value)) or value is lib.no_default:
-return True
-
-raise TypeError(
-"Cannot do inplace boolean setting on "
-"mixed-types with a non np.nan value"
-)
-
-return True
-
 @final
 def _get_numeric_data(self) -> Self:
 return self._constructor(self._mgr.get_numeric_data()).__finalize__(self)
@@ -10036,7 +10020,6 @@ def _where(
 # we may have different type blocks come out of putmask, so
 # reconstruct the block manager
 
-self._check_inplace_setting(other)
 new_data = self._mgr.putmask(mask=cond, new=other, align=align)
 result = self._constructor(new_data)
 return self._update_inplace(result)

@@ -514,10 +514,6 @@ def to_native_types(self, **kwargs) -> Self:
 """
 return self.apply("to_native_types", **kwargs)
 
-@property
-def is_numeric_mixed_type(self) -> bool:
-return all(block.is_numeric for block in self.blocks)
-
 @property
 def any_extension_types(self) -> bool:
 """Whether any of the blocks in this manager are extension blocks"""

@@ -401,10 +401,23 @@ def test_where_none(self):
 {"A": np.nan, "B": "Test", "C": np.nan},
 ]
 )
-msg = "boolean setting on mixed-type"
 
-with pytest.raises(TypeError, match=msg):
-df.where(~isna(df), None, inplace=True)
+orig = df.copy()
+
+mask = ~isna(df)
+df.where(mask, None, inplace=True)
+expected = DataFrame(
+{
+"A": [1.0, np.nan],
+"B": [None, "Test"],
+"C": ["Test", None],
+}
+)
+tm.assert_frame_equal(df, expected)
+
+df = orig.copy()
+df[~mask] = None
+tm.assert_frame_equal(df, expected)
 
 def test_where_empty_df_and_empty_cond_having_non_bool_dtypes(self):
 # see gh-21947